This 648-mile Route Is the Longest Road Trip in the U.S. With No Restrooms—and It Takes More Than 10 Hours #Travel Here’s what you need to know so you can hit the open road worry-free.

Here's what you need to know so you can hit the open road worry-free.<div class="media_block"><a href="https://www.travelandleisure.com/thmb/AH7hLexMh2td7C5r8USCPdtNDEQ=/filters:no_upscale():max_bytes(150000):strip_icc():format(jpeg)/TAL-theodore-roosevelt-national-park-highway-LONGESTUSRT0226-d4261f6ad19946f5880d0a993f6c02ad.jpg"><img src="https://www.travelandleisure.com/thmb/AH7hLexMh2td7C5r8USCPdtNDEQ=/filters:no_upscale():max_bytes(150000):strip_icc():format(jpeg)/TAL-theodore-roosevelt-national-park-highway-LONGESTUSRT0226-d4261f6ad19946f5880d0a993f6c02ad.jpg" class="media_thumbnail"></a></div>