This historic route is one of the best ways to see the American West, passing vast plains, mountains, and deserts.<div class="media_block"><a href="https://www.travelandleisure.com/thmb/lyCRvQ9_WKRz-9BNAHTshRYLoEw=/filters:no_upscale():max_bytes(150000):strip_icc():format(jpeg)/TAL-header-pony-express-trail-sign-PONYEXPRESSTRAIL0126-fb56a5b6cff648d9ac15936d2c712cbe.jpg"><img src="https://www.travelandleisure.com/thmb/lyCRvQ9_WKRz-9BNAHTshRYLoEw=/filters:no_upscale():max_bytes(150000):strip_icc():format(jpeg)/TAL-header-pony-express-trail-sign-PONYEXPRESSTRAIL0126-fb56a5b6cff648d9ac15936d2c712cbe.jpg" class="media_thumbnail"></a></div>
This historic route is one of the best ways to see the American West, passing vast plains, mountains, and deserts.
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